克罗米酚对男性低促性腺素性功能减退症合理

纽约（消息来源健康版）1月四日报导：据发表在12月选集的《生育与子代》杂志的一项调查报告援引克罗米酮对部分极低促连续性腺素连续性特性大不如前的男连续性高血压险恶。来自伯明罕阿拉巴马所学校的该调查报告的第一作者Scott J. Whitten博士在接受路透通讯社采访时话说：“原发连续性或获得连续性HH高血压在接受漠视连续性更多和更昂贵的疗程（例如施用促连续性腺激素类）在此之前透过4个月的克罗米酮试验连续性疗程是险恶的。”Whitten博士和老友研究者了克罗米酮对10名HH男连续性高血压（HH是导致男连续性子代的少见因素）是否适当。调查报告并称克罗米酮疗程1年后，4名卡尔曼(宰)综合征高血压之中只有一名高血压的体外剂量增加而全脑下垂体特性大不如前症高血压的体外缺乏征状仅没有得到改善。相反，该调查报告援引3名成年发病的原发连续性HH男连续性高血压经过3个月克罗米酮的疗程体外剂量有了明显增加。现阶段该组高血压较早两名完全恢复了受孕。Whitten博士话说：“除非对克罗米酮疗程没有反应，我们不会因为征状暂时之中止对高血压使用该药剂。”最后作者总结话说：“因为条件受限，对HH高血压促连续性腺激素类药剂和克罗米酮的随机研究者不易透过，然而利用多系列的宽松选择标准对高血压透过分级制度可能为了让进一步可验证克罗米酮完全恢复男连续性极低受孕的适当连续性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编辑：红色梦幻

编辑： 张靖